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unraveling complexity, from patient to therapy

 Our mission: redefine diseases using patient transcriptomics data to uncover hidden drug targets


PROBLEM:
​>85% of drugs fail in the clinic, mostly because their targets are ineffective

OUR SOLUTION:
​Start with patients and work backwards toward targets & drugs that work


​HOW WE DO IT:
​

Unravel begins with patients, using their RNA to define each disease using molecular data. Our proprietary probabilistic network model of human health predicts drugs to restore a disease back to health, screening 40,000+ compunds in silico with 200x the hit rate of typical drug screens. Our unbiased screening 
platform further downselects hits that work in a whole organism, letting us ask clinically-relevant questions from the start. We then use these drugs to find new, hidden drug targets, validate them in the clinic, and develop new therapies.

​The result: we decode patients' diseases to enable effective therapeutics, quickly and with lower development risk. 


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We can't do this alone.

We are committed to getting patients effective drugs the fastest way possible. We partner with companies, foundations, and researchers to amplify their strengths and datasets through cost-effective decision-making in the areas of target discovery, mechanism identification, drug optimization, and patient stratification for small molecules and biologics.
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